Researchers from Singapore General Hospital (SGH) and the National University of Singapore (NUS) have discovered that pulsed electromagnetic fields can stimulate muscle tissue to mimic exercise benefits for patients with type 2 diabetes and excess belly fat. This non-invasive treatment, known as magnetic mitohormesis, activates metabolic pathways similar to those triggered by endurance exercise, potentially improving glucose control without physical exertion.
The exploratory study, conducted at SGH from June 2023 to January 2024, involved 40 adults with poorly controlled type 2 diabetes. Participants underwent weekly 10-minute sessions where their leg muscles were stimulated by a gentle magnetic field. Notably, nearly 90% of patients with central obesity experienced improved blood glucose control, with their HbA1c levels dropping from 7.5% to 7.1% over three months.
Dr Tan Hong Chang, Senior Consultant at SGH, highlighted the significance of this treatment for patients unable to exercise due to age or health issues. “This treatment could give similar benefits to exercise without having to work out physically,” he stated.
The study, supported by the Agency for Science, Technology and Research (A*STAR) and QuantumTX Pte Ltd, was published in the Journal of Clinical Medicine in September 2025. Whilst promising, larger trials are necessary before widespread implementation. Future research will focus on optimal treatment duration and identifying patient profiles that benefit most. Professor Alfredo Franco-Obregón from NUS emphasised the potential of this therapy in various health applications, noting its ability to lower inflammation and improve health outcomes.
